Adam and Danielle Busby defy all odds by giving birth to the first set of all girl quintuplets in the US. After four months in the NICU, the quints come home and along with four-year-old sister Blayke, turn Adam and Danielle's lives upside down.
Adam returns to work, leaving Danielle to care for the quintuplets and Blayke by herself for the first time. On Adam's first day back, Hazel falls ill with a fever, leaving the family scrambling and Danielle feeling overwhelmed and alone.
The Busbys take a road trip to Lake Charles to help Mimi with her garage sale, and Danielle learns some shocking news from her mom. Meanwhile Danielle & Adam wrestle with a difficult decision of whether or not to allow Hazel to have eye surgery.
When Danielle catches the flu, Mimi struggles to take care of 5 babies on her own. Adam plans a 10-year anniversary surprise for Danielle. Later, when Danielle gives a speech for the hospital, she faces the painful past of having premature babies.
It's Halloween, but before the Busbys can celebrate the Quints' first trick-or-treat outing, they have to find costumes, shop for pumpkins and get the new house ready for a Halloween party, all while making a final decision on a $100,000 investment.
It's the quints' first family vacation! But with five toddlers running wild, it may feel more like work than vacation time for Adam and Danielle. Meanwhile, Adam struggles to tell his brother-in-law, and boss, about the new business he's starting.